We discovered the transcriptomic signature of human endometrial receptivity.
Now, we are focusing on a new, minimally invasive procedure using single-cell analysis.
Research in Reproductive Medicine
Our activity predominantly involves research in the field of Reproductive Medicine, with a particular focus on the fields of regenerative medicine concerning the endometrium and genomic studies on embryonic viability and endometrial receptivity, as well as other factors that cause infertility.
Our research lines include:
Felipe Vilella, PhD
We have investigated how the mother communicates with the preimplantation embryo prior to implantation, and discovered that the maternal endometrium modifies the transcriptomics of the embryo in health and disease.
The language use in this dialogue is composed by extracellular vesicles, miRNA and DNA secreted by the endometrium to the endometrial fluid that is internalized by the embryo modifying its transcriptome.
Xavier Santamaria MD, PhD
We have identified the existence of human endometrial stem cells and have further clarified their origin from the endogenous source (endometrium) and from the bone marrow.
We have demonstrated the therapeutic potential of autologous bone marrow CD133+ stem cells in the treatment of non-curable endometrial pathologies such as Asherman’s syndrome or endometrial atrophy.
Carmen Rubio, PhD
Our previous clinical research has already shown the benefits of preimplantation genetic testing for aneuploidies (PGT-A) to increase live birth rates and decrease miscarriages and time to pregnancy.
Now, we aim to develop a non-invasive approach to identify euploid embryos for transfer by assessing the cell-free DNA secreted by the embryo without the need for embryo biopsy.
Tamara Garrido, PhD
Pre-eclampsia is an obstetric condition affecting 5% of all pregnancies, with high impact on mortality and morbidity of both mother and child.
Our research has provided evidence that endometrial decidualization resistance is implicated in the origin of this disease. This finding offers a new perspective based on the maternal contribution to gestation, aiming to develop a tool that will diagnose pre-eclampsia.
Felipe Vilella, PhD/Pradeep Reddy, PhD
Creation of artificial gametes is a long-term goal in the field of infertility research.
Our lab has demonstrated the possibility of converting somatic cells into primordial germ cell-like cells by inducing the expression of germ cell genes.